Drug prevents diabetes recurrence after islet transplantation
Contact: Bob Beard reb8evirginia.edu (USA) 434-982-4490 University of Virginia Health System (USA) Charlottesville, VA (USA) prevents a new anti-inflammatory compound called Lisofylline returns after diabetes islet cells are transplanted insulin-making in diabetic mice after a new study by researchers at the University of Virginia Health System. The study is in the 20th January issue of the journal Transplantation. islet transplantation has become a promising treatment for type 1 diabetes in humans in recent years.But without several powerful immunosuppressive drugs, the bodys immune system destroying the transplanted islet cells in transplant patients with deficiency of insulin, excess glucose in the blood and the return of diabetes. Lisofylline or LSF, has the potential
to take this into the destruction of cells by preventing the preservation of insulin secretion by pancreatic beta cells in the presence of autoimmune-inflammatory cytokines known attacker, according to the University of Virginia researchers. Our results are very encouraging and we are pleased that lisofylline worked so well in this animal model, said Dr.Jerry Nadler, director of the Division of Endocrinology and Metabolism at the University of Virginia and director of the diabetes and excellence hormone.We discovered a potentially new way to protect the transplant of islet cells in clinical settings. Its possible that research could be the basis for further studies of the LSF or related anti-inflammatory compounds used in humans to limit the need for more toxic
immunosuppressive drugs in patients with islet cell transplant. In the study, diabetic mice that can mount an autoimmune attack have received islet transplantation in the kidneys, followed by daily injections of LSF for 3 weeks. A control group was treated only with saline.The test results showed blood sugar that mice treated with LSF maintains healthy blood sugar levels, without immunosuppressants and insulin, for more than 65 Pages: [1] 2