Diuretic can not be the best way to reduce water retention CHF
Researchers believe they have identified a new agent to reduce the accumulation of excess fluid in patients with congestive heart failure, which prevents the parent sodium-depleting effects of diuretics, drugs commonly used today for this purpose. The study drug, called lixivaptan, appears to be as effective as a diuretic to help patients to remove excess water and has the advantage of maintaining adequate levels of sodium in the body, said Dr. William Abraham, director of cardiovascular medicine at Ohio State University Medical Center and lead author of a study of this drug.The results of the study are published in the April issue of the Journal of the American College of Cardiology. Abraham is also the principal investigator for a future international multi-center Phase
3 to better evaluate the effectiveness of the drug. Diuretics are part of life for many patients with congestive heart failure, a disease caused by water retention, which can lead to shortness of breath, swelling of legs and ankles, and characterized the progressive weakening of the heart. Although they are key to reducing fluid, diuretics can cause the kidneys more sodium than water, may have to excrete the harmful effects.An abnormally low concentration of sodium in the blood leads to a disease other than chronic hyponatremia can lead to slow thinking and memory problems, and indicates a poor prognosis for patients with heart failure.Lixivaptan acts by blocking vasopressin, an anti-hormone, the kidneys to retain water, causes. When the body must stay hydrated under
certain conditions, vasopressin can have protective effects. But an excess of vasopressin is counterproductive in a body fluid, while Abraham said. This drug is an antagonist of the vasopressin receptor, eliminated so that the signals from the kidneys, water, salt, said Abraham, who is also associate director of clinical research / Ohio States Davis Heart and Lung Research Institute.It changes the balance of water and electrolytes Sumatriptan online price buy by the pillPages: [1] 2