Clinical studies of Alzheimers disease drug shows clear reductions in AD development
Contact: Heidi Foden h.fodenucl.ac.uk 44-207-679-1618 University College London (United Kingdom) A new clinical trial showed that treatment of Alzheimers disease slowed the progression of cognitive impairment in a group of patients with moderate to severe symptoms. Test results on the effectiveness of the treatment of AD drug clioquinol, carried out by the UCI Department of Psychiatry and Behavioral Sciences and Prana Biotechnology Limited, established in the new issue of Archives of Neurology, published Monday, 15 December.The study included 36 patients who were evaluated for indicators of cognitive performance such as memory, orientation, language, attention and thinking. The results were analyzed using a cognitive scores in Alzheimers Disease Assessment Scale, a score
of ADAS-cog called. The scores range from 0 to 70, with lower values ​​indicating a healthy adult. Dementia progresses to the guests. Eighteen patients were assigned to placebo and 18 received Prana Alzheimers drugs, the PBT-1 (clioquinol) (the first of Prana develop metal protein attenuating compounds (MPACS a) Alzheimers disease).PBT-1 is a chemical that binds zinc and copper has been shown that the level of A and the associated toxicity in the brain of transgenic mice as a model for Alzheimers disease used less. Patients most affected Pranas enter pilot clinical study (those with higher values ​​ADAS-cog) showed a mean change score at 24 weeks by about 1.5 points on PBT-1 and about 8.9 in the placebo group, a difference of 7, 4 Generally, untreated patients with
moderate illness probably six to 12 points on the gain of the ADAS-cog score over 12 months.A panel convened by the Food and Drug Administration in the United States, considered an improvement of four points would be clinically significant.The results of this study were very encouraging for a clinician, Dr. Ritchie said of the UCL, who led the study, adding, Our results have led to the development of Prana Biotechnology
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