Bacterial protein recycling factor possible key to the new class of antibiotics
Understanding the last step of protein synthesis of the basic process of translating DNA into its final protein product becomes even more clear both literally and metaphorically. This last phase, called recycling, is essential for the proper functioning of all cells. Using Cryo-electron microscopy to directly observe the three dimensional structure of the protein, researchers at the University of Pennsylvania School of Medicine, State University of New York, Albany, you can now see the exact configuration of a molecule called the ribosome recycling factor (RRF) in the bacterium Escherichia coli commune.(Click on the thumbnail to see full size image). Image reported in June 15 Issue of Proceedings of the National Academy of Sciences, could help guide the design of new antibiotics
to inhibit the steps required for protein synthesis RRF.Every living thing is, this last step, the recycling of equipment dedicated to the synthesis of proteins for the next round of translation, says Akira Kaji, PhD, Professor of Microbiology at Penn. Interestingly, at this time, this fundamental process remained vague until we began our studies SRR. Most antibiotics affect protein synthesis work by stopping its molecular mechanism. But still no goal to recycle step. We FRR is one of the best candidates for a new antibiotic target because the mechanism of recycling machinery manufacturing is different proteins involved in the prokaryotes and eukaryotes, which is human to bacteria, said Kaji.With the emergence of antibiotic-resistant organisms, this is the best way for the
development of new antibiotics.Thirty years of research The ribosome is the structure inside the cells in which amino acids are linked together to make proteins using transfer RNA (tRNA) and messenger RNA (mRNA). Kaji has to work over the past 30 years, which for the last step of protein synthesis. RRF, in conjunction with the elongation factor G (EF-G), moves the mRNA and tRNA ribosome remove, so it is ready cheap cipralex
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